Even if you change those parameters, a huge file could still drain your memory. So a better choice will be to intercept the upload and deal with the large file stream directly, see (sorry, not VB code):
http://groups.google.com/groups?hl=en&lr=&ie=UTF-8&oe=UTF-8&selm=4244cc4e.0206271050.1cb75650%40posting.google.com
http://groups.google.com/groups?hl=en&lr=&ie=UTF-8&oe=UTF-8&selm=4244cc4e.0206271050.1cb75650%40posting.google.com
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