can you ping the 200 machine? are you using COM+? seehttp://groups.google.com/groups?q=System.Runtime.InteropServices.COMException:+Exception+from+HRESULT:+0x8004D00E&hl=en&lr=&ie=UTF-8&oe=UTF-8&selm=3e036a6d%241%40news.microsoft.com&rnum=3