string str = @"<li class=""ico_tel""><span class=""pri"" id=""t_phone"">
18249375857
</span>";
Regex reg = new Regex(@"(?is)<li class=""ico_tel""><span class=""pri"" id=""t_phone"">\s*(\d+)\s*</span>");
Console.WriteLine(reg.Match(str).Groups[1].Value);
18249375857
</span>";
Regex reg = new Regex(@"(?is)<li class=""ico_tel""><span class=""pri"" id=""t_phone"">\s*(\d+)\s*</span>");
Console.WriteLine(reg.Match(str).Groups[1].Value);
<li class=""ico_tel""><span class=""pri"" id=""t_phone"">.*?</span>