求助，mysql Database access problem. Killing off all remaining connections

[2018-12-17 13:54:52,910]-[ERROR]-[ConnectionHandle:297]-Database access problem. Killing off all remaining connections in the connection pool. SQL State = 08S01
[2018-12-17 13:54:52,918]-[ERROR]-[qtong:152]-异常信息如下：
com.mysql.jdbc.exceptions.jdbc4.CommunicationsException: Communications link failureThe last packet successfully received from the server was 160,590 milliseconds ago.  The last packet sent successfully to the server was 30 milliseconds ago.
at sun.reflect.NativeConstructorAccessorImpl.newInstance0(Native Method)
at sun.reflect.NativeConstructorAccessorImpl.newInstance(NativeConstructorAccessorImpl.java:62)
at sun.reflect.DelegatingConstructorAccessorImpl.newInstance(DelegatingConstructorAccessorImpl.java:45)
at java.lang.reflect.Constructor.newInstance(Constructor.java:423)
at com.mysql.jdbc.Util.handleNewInstance(Util.java:411)
at com.mysql.jdbc.SQLError.createCommunicationsException(SQLError.java:1116)
at com.mysql.jdbc.MysqlIO.reuseAndReadPacket(MysqlIO.java:3102)
at com.mysql.jdbc.MysqlIO.reuseAndReadPacket(MysqlIO.java:2991)
at com.mysql.jdbc.MysqlIO.checkErrorPacket(MysqlIO.java:3532)
at com.mysql.jdbc.MysqlIO.sendCommand(MysqlIO.java:2002)
at com.mysql.jdbc.MysqlIO.sqlQueryDirect(MysqlIO.java:2163)
at com.mysql.jdbc.ConnectionImpl.execSQL(ConnectionImpl.java:2618)
at com.mysql.jdbc.ConnectionImpl.setAutoCommit(ConnectionImpl.java:5000)
at com.jolbox.bonecp.ConnectionHandle.setAutoCommit(ConnectionHandle.java:1063)
at com.kframe.kdb.DB.getConnection(DB.java:82)
at com.qtong.zhdj.jypt.mysqlimpl.IntegralManagerImpl.addIntegralByLookFile(IntegralManagerImpl.java:33)
at com.qtong.zhdj.jypt.webintf.tablemanager.IntegralAction.addIntegralByLookFile(IntegralAction.java:46)
at com.qtong.zhdj.jypt.webintf.tablemanager.IntegralAction.execute(IntegralAction.java:24)
at com.kframe.kframe.KFrameDispatcher.doCommand(KFrameDispatcher.java:124)
at com.kframe.kframe.KFrameDispatcher.doPost(KFrameDispatcher.java:93)
at javax.servlet.http.HttpServlet.service(HttpServlet.java:661)
at javax.servlet.http.HttpServlet.service(HttpServlet.java:742)
at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:231)
at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:166)
at org.apache.tomcat.websocket.server.WsFilter.doFilter(WsFilter.java:52)
at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:193)
at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:166)
at com.kframe.CharacterEncodingFilter.doFilter(CharacterEncodingFilter.java:25)
at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:193)
at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:166)
at org.apache.catalina.core.StandardWrapperValve.invoke(StandardWrapperValve.java:198)
at org.apache.catalina.core.StandardContextValve.invoke(StandardContextValve.java:96)
at org.apache.catalina.authenticator.AuthenticatorBase.invoke(AuthenticatorBase.java:478)
at org.apache.catalina.core.StandardHostValve.invoke(StandardHostValve.java:140)
at org.apache.catalina.valves.ErrorReportValve.invoke(ErrorReportValve.java:80)
at org.apache.catalina.valves.AbstractAccessLogValve.invoke(AbstractAccessLogValve.java:650)
at org.apache.catalina.core.StandardEngineValve.invoke(StandardEngineValve.java:87)
at org.apache.catalina.connector.CoyoteAdapter.service(CoyoteAdapter.java:342)
at org.apache.coyote.http11.Http11Processor.service(Http11Processor.java:799)
at org.apache.coyote.AbstractProcessorLight.process(AbstractProcessorLight.java:66)
at org.apache.coyote.AbstractProtocol$ConnectionHandler.process(AbstractProtocol.java:868)
at org.apache.tomcat.util.net.NioEndpoint$SocketProcessor.doRun(NioEndpoint.java:1457)
at org.apache.tomcat.util.net.SocketProcessorBase.run(SocketProcessorBase.java:49)
at java.util.concurrent.ThreadPoolExecutor.runWorker(ThreadPoolExecutor.java:1149)
at java.util.concurrent.ThreadPoolExecutor$Worker.run(ThreadPoolExecutor.java:624)
at org.apache.tomcat.util.threads.TaskThread$WrappingRunnable.run(TaskThread.java:61)
at java.lang.Thread.run(Thread.java:748)
Caused by: java.io.EOFException: Can not read response from server. Expected to read 4 bytes, read 0 bytes before connection was unexpectedly lost.
at com.mysql.jdbc.MysqlIO.readFully(MysqlIO.java:2552)
at com.mysql.jdbc.MysqlIO.reuseAndReadPacket(MysqlIO.java:3002)
... 40 more
com.mysql.jdbc.exceptions.jdbc4.CommunicationsException: Communications link failureThe last packet successfully received from the server was 160,590 milliseconds ago.  The last packet sent successfully to the server was 30 milliseconds ago.
at sun.reflect.NativeConstructorAccessorImpl.newInstance0(Native Method)
at sun.reflect.NativeConstructorAccessorImpl.newInstance(NativeConstructorAccessorImpl.java:62)
at sun.reflect.DelegatingConstructorAccessorImpl.newInstance(DelegatingConstructorAccessorImpl.java:45)
at java.lang.reflect.Constructor.newInstance(Constructor.java:423)
at com.mysql.jdbc.Util.handleNewInstance(Util.java:411)
at com.mysql.jdbc.SQLError.createCommunicationsException(SQLError.java:1116)
at com.mysql.jdbc.MysqlIO.reuseAndReadPacket(MysqlIO.java:3102)
at com.mysql.jdbc.MysqlIO.reuseAndReadPacket(MysqlIO.java:2991)
at com.mysql.jdbc.MysqlIO.checkErrorPacket(MysqlIO.java:3532)
at com.mysql.jdbc.MysqlIO.sendCommand(MysqlIO.java:2002)
[2018-12-17 13:54:52,922]-[DEBUG]-[qtong:47]-返回结果json：{"success":false}
at com.mysql.jdbc.MysqlIO.sqlQueryDirect(MysqlIO.java:2163)
at com.mysql.jdbc.ConnectionImpl.execSQL(ConnectionImpl.java:2618)
at com.mysql.jdbc.ConnectionImpl.setAutoCommit(ConnectionImpl.java:5000)
at com.jolbox.bonecp.ConnectionHandle.setAutoCommit(ConnectionHandle.java:1063)
at com.kframe.kdb.DB.getConnection(DB.java:82)
at com.qtong.zhdj.jypt.mysqlimpl.IntegralManagerImpl.addIntegralByLookFile(IntegralManagerImpl.java:33)
at com.qtong.zhdj.jypt.webintf.tablemanager.IntegralAction.addIntegralByLookFile(IntegralAction.java:46)
at com.qtong.zhdj.jypt.webintf.tablemanager.IntegralAction.execute(IntegralAction.java:24)
at com.kframe.kframe.KFrameDispatcher.doCommand(KFrameDispatcher.java:124)
at com.kframe.kframe.KFrameDispatcher.doPost(KFrameDispatcher.java:93)
at javax.servlet.http.HttpServlet.service(HttpServlet.java:661)
at javax.servlet.http.HttpServlet.service(HttpServlet.java:742)
at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:231)
at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:166)
at org.apache.tomcat.websocket.server.WsFilter.doFilter(WsFilter.java:52)
at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:193)
at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:166)
at com.kframe.CharacterEncodingFilter.doFilter(CharacterEncodingFilter.java:25)
at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:193)
at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:166)
at org.apache.catalina.core.StandardWrapperValve.invoke(StandardWrapperValve.java:198)
at org.apache.catalina.core.StandardContextValve.invoke(StandardContextValve.java:96)
at org.apache.catalina.authenticator.AuthenticatorBase.invoke(AuthenticatorBase.java:478)
at org.apache.catalina.core.StandardHostValve.invoke(StandardHostValve.java:140)
at org.apache.catalina.valves.ErrorReportValve.invoke(ErrorReportValve.java:80)
at org.apache.catalina.valves.AbstractAccessLogValve.invoke(AbstractAccessLogValve.java:650)
at org.apache.catalina.core.StandardEngineValve.invoke(StandardEngineValve.java:87)
at org.apache.catalina.connector.CoyoteAdapter.service(CoyoteAdapter.java:342)
at org.apache.coyote.http11.Http11Processor.service(Http11Processor.java:799)
at org.apache.coyote.AbstractProcessorLight.process(AbstractProcessorLight.java:66)
at org.apache.coyote.AbstractProtocol$ConnectionHandler.process(AbstractProtocol.java:868)
at org.apache.tomcat.util.net.NioEndpoint$SocketProcessor.doRun(NioEndpoint.java:1457)
at org.apache.tomcat.util.net.SocketProcessorBase.run(SocketProcessorBase.java:49)
at java.util.concurrent.ThreadPoolExecutor.runWorker(ThreadPoolExecutor.java:1149)
at java.util.concurrent.ThreadPoolExecutor$Worker.run(ThreadPoolExecutor.java:624)
at org.apache.tomcat.util.threads.TaskThread$WrappingRunnable.run(TaskThread.java:61)
at java.lang.Thread.run(Thread.java:748)
Caused by: java.io.EOFException: Can not read response from server. Expected to read 4 bytes, read 0 bytes before connection was unexpectedly lost.
at com.mysql.jdbc.MysqlIO.readFully(MysqlIO.java:2552)
at com.mysql.jdbc.MysqlIO.reuseAndReadPacket(MysqlIO.java:3002)
... 40 more